News and Improvements

• KRAS EXTERNAL QUALITY

  Our Center has joined the external quality control studies carried out by European Society of Pathology (ESP) again in European EQA program for testing KRAS mutations in colorectal cancer and has received certificate for KRAS DNA analsis in 2012.
  
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• HPV DNA ANALYSIS

  Our center is also started to use the chip technology since 2006 on December. With this technology, it is possible to screening the Human Popilloma Virus ( HPV) that increases the risk of serviks.
  
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• CYSTIC FIBROSIS CERTIFICATION

  In 2010, our Center has received certificate for Cystic Fibrosis DNA analysis.
  
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• CANAVAN DISEASE (ASPA)

  Our Center is able to perform DNA Analysis for Canavan Disease. The ASPA gene mutations (whole gene) constituting 90% of the mutations observed in patients can be identified with DNA sequencing analysis.
  
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• RETT DNA ANALYSIS (MECP2)

  Our Center is able to perform DNA Analysis for Rett Syndrome. The MECP2 gene mutations (whole gene) constituting 80% of the mutations observed in patients can be identified with DNA sequencing analysis.
  
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• RETT DNA ANALYSIS

  The deletions and duplications in MECP2, CDKL5, ARX and NTNG1 genes causing Rett Syndrome can be determined with fragment analysis method.
  
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• CADASIL DNA ANALYSIS

  Our Center is able to perform DNA analysis for CADASIL Syndrome. The NOTCH3 gene mutations (exons 3, 4, 11, 18 and 19) constituting 70-75% of the mutations observed in patients can be identified with DNA sequencing analysis.
  
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• IGF1R FISH ANALYSIS

  Our Center performs IGF1R (15q26) FISH analysis, which has a supporting role in determining the treatment protocols of patients with non-small cell lung cancer (NSCLC) .
  
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• EML4-ALK FISH ANALYSIS

  Our Center performs EML4-ALK (2p23) FISH analysis, which has a supporting role in determining the treatment protocols of patients with non-small cell lung cancer (NSCLC) .
  
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• EXTERNAL QUALITY CONTROL

  In 2010, our Center has received certificate for chromosome analysis, DNA sequencing analysis (DNA-SEQ full) and mutation scan (MSCAN).
  
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• MICROSATELLITE INSTABILITY (MSI)

  The MSI analysis performed on the patients with Hereditary Nonpolyposis Colorectal Cancer is available in our Center.
  
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• FRIEDREICH'S ATAXIA

  The Frataxin gene causing Friedreich's Ataxia can also be diagnosed in our Center. Furthermore, the deletion and duplications in the same gene can be examined with DNA fragment analysis.
  
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• HUNTINGTON DISEASE (HD)

  Our Center has started DNA analysis for CAG repetitions causing Huntington Disease.
  
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• TOP2A FISH ANALYSIS

  Our Center performs TOP2A FISH analysis, which has a supporting role in determining the treatment protocols of patients with breast cancer.
  
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• CARDIOFACIOCUTANEOUS SYNDROME

  Our Center is able to perform DNA analysis for Cardiofaciocutaneous (CFC) Syndrome. The BRAF gene mutations (6 and 11-16th exons) constituting 75-80% of the mutations observed in patients can be identified with DNA sequencing analysis.
  
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• SMITH-LEMLI-OPITZ SYNDROME

  Our Center is able to perform DNA analysis for Smith-Lemli-Opitz (SLOS) syndrome. 1237-1G>C (IVS8-1G>C) and T93M mutations constituting 40% of the mutations observed in patients can be identified with DNA sequencing analysis.
  
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• DYSTONIA (DYT1) DNA ANALYSIS

  TOR1A mutations causing Dystonia Type 1 (Dystonia Musculorum Deformans 1) disease can be diagnosed with DNA sequencing analysis in our Center. In the patients, GAG deletions causing disease in 5th exon of TOR1A gene is examined.
  
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• BRAF DNA ANALYSIS

  BRAF gene mutations (ekzon 11 and 15 - including V600) are examined in our Center since 2010.
  
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• HLA B27

  The existence of HLA-B27 used in determining the susceptibility to autoimmune diseases such as Ankylosing Spondylitis can be determined in our Center with DNA analysis method.
  
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• CELIAC DISEASE

  The Celiac Disease (Gluten Enteropathy) diseases can be diagnosed in our Center with DNA analysis method.
  
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• FIP1L1/PDGFRA FISH ANALYSIS

  FIP1L1/PDGFRA fusion used before Gleevec/Imatinib treatment in patients with Idiopathic Eosinophilic Syndrome or Chronic Eosinophilic Leukemia is available in our Center with FISH analysis.
  
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• WILLIAMS SYNDROME

  The Williams Syndrome can be diagnosed in our Center with FISH analysis.
  
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• MICRODELETION SYNDROMES

  The microdeletion syndromes such as DiGeorge , Prader Willi/Angelman, Cri-du-Chat, Wolf-Hirschhorn, Kallman, Williams and Smith-Magenis Syndrome can be diagnosed in our Center with FISH analysis.
  
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• GLIOMA

  1p and 19q zone loss having an important role in the treatment of gliomas can be diagnosed in our Center with FISH analysis.
  
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• ALFA THALASSEMIA

  In our Center, the deletions and duplications causing alpha thalassemia can be diagnosed with MLPA technique.
  
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• KRAS DNA ANALYSIS

  All of Kras gene zone codon 12&13, 61 and 146 mutations are examined in our Center since 2006.
  
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• CARDIOVASCULAR RISK PANEL

  The cardiovascular risk panel, frequently requested by couples with repeating pregnancy losses, has started in our Center. Today, the test is frequently used for determining the susceptibility to cardiovascular diseases. Within the scope of the test, the following genetic zones can be evaluated and 12 different mutations (genetic mutations) occurring at 10 different genetic zones can be examined.
  
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• ACTN3

  Our Center has started to perform DNA test for ACTN3, which is used in evaluating the spore performance. In this study, the R577X mutation within ACTN3 gene is examined.
  
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• P16 (CDKN2A) DNA ANALYSIS

  In our Center, it is possible to diagnose the mutations by examining them with DNA sequence analysis method for P16 (CDKN2A) gene zone, which has an important role in the development of malign melanoma.
  
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• P53 DNA ANALYSIS

  In our Center, it is possible to diagnose the mutations by examining them with DNA sequence analysis method for P53 gene.
  
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• DMD/BMD DNA ANALYSIS

  In our Center, the deletions and duplications causing Duchenne/Becker Muscular Dystrophies can be diagnosed with MLPA technique.
  
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• FAMILIAL MEDITERRANEAN FEVER (FMF)

  DNA analysis is conducted at our center since 2006 needed for FMF disease. Primarily 12 mutations that are best observed at people are controlled.
  
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• LEUKEMIA&LYMPHOMA

  On leukaemia patients (FISH) moleculer cytogenetics tests (translocations, inversion, deletion etc). for defining the cancer type, guessing the clinical control, defining the type of the treatment and to detect the disease in the early stage of the disease to detect the disease recurrence can be realized at our medical center since 2006 on December.
  
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• CHIP TECHNOLOGY

  Our center is also started to use the chip technology since 2006 on December.
  
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• BRCA DNA ANALYSIS

  At people suffering breast and over cancers, checking the gene areas of BRCA1 and BRCA2 is conducted at our center.
  
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• HER2/NEU

  On December 2006, the analysis of Her2/Neu FISH that make it possible to define the treatment protocol on people who have suffered breast cancer got started.
  
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• COUMADIN TOXICITY

  The pharmacogenetic analyses requested from the patients before Coumadin treatment are available in our Center. CYP2C9 and VKORC1 region are examined in the patients.
  
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• EGFR DNA ANALYSIS

  At our center EGFR DNA analysis leading treatment protocol is started to be realized on patients having Lung cancer since 2007 0n January.
  
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• GENDIA

  Our center has made a co-operation protocol with Institute of Medical Molecular Diagnostic Inc. on january of 2007 to implement genetic tests.
  
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• PDGFRA and KIT

  The studies of checking KIT and PDFGRa gene areas leading the treatment protocol at GIST cancers are on the last stage.
  
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• ACHONDROPLASIA

  At our center genetic diagnosis tests are realized for Achondroplasia, Hypocondroplasia and Thanatophoric Dysplasia.
  
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• OSTEOPOROSIS

  The genetic mutations causing osteoporosis disease can be examined in our Center. The following polymorphisms can be determined within this scope.
  
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• ABL1 DNA ANALYSIS

  The DNA analyses for ABL1, which is important for hematology patients before Gleevec/Imatinib treatment, is available in our Center.
  
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• SPINAL MUSCULAR ATROPHY (SMA)

  Disease and porter tests with DNA fragment analysis are available in our Center for Spinal Muscular Atrophy (SMA), which is a frequently observed and genetic disease.
  
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• JAK2 DNA ANALYSIS

  V617F mutation, which is one of the most frequently observed genetic mutations in chronic myeloproliferative diseases (polycytemia vera, essential thrombocytopenia, chronic idiopathic myelofibrosis etc.) and where JAK2 gene is observed, is examined with real-time PCR method in our Center.
  
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• RET DNA ANALYSIS

  Ret gene, having a role in the development of thyroid cancer, is examined with DNA sequence analysis method and the mutations can be diagnosed in our Center.
  
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• ISO 9001:2008

  In 2010, our Center has received ISO 9001:2008 quality management system certificate given by the certification body Udem.
  
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• BETA THALASSEMIA

  HBB (beta globin) gene, having a role in the development of Beta Thalassemia, is examined with DNA sequencing analysis method and the mutations can be diagnosed in our Center.
  
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• FRAGILE X DNA ANALYSIS

  Our Center has started DNA analysis for CGG repeats causing Fragile X Disease.
  
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• CYSTIC FIBROSIS

  Our Center is able to perform DNA Analysis for Cystic Fibrosis Disease. The CFTR gene mutations (whole gene) constituting 97-98% of the mutations observed in patients can be identified with DNA sequencing analysis.
  
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• PREIMPLANTATION GENETIC DIAGNOSIS

  New developments on genetic technology are providing genetic explorations on embryos, created as IVF.
  
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