Down syndrome(DS) is the most commonly observed chromosomal abnormality and occurrence frequency is one out of every 600-700 births. Since it has its own unique peculiarities , it can be identified at birth.

Patients show those traits which are hypotonia, brachiocephali, upward slanting palpebral fissures, epicantus, iris Brushfield spots, depressed nasal bridge, low set ears, a single transverse line and clinodactyly in hands, a large gap between the first and second fingers on feet.