PHARMACOGENETIC TESTS

Molecular Genetics

  • EGFR DNA analysis (exon 18-21) - Lung cancer (Gefitinib/Iressa & Erlotinib/Tarceva)
  • K-ras DNA analysis (exon 1-3) (codon 12&13, codon 61 and codon 146)
  • PDGFRA DNA analysis - GIST (Imatinib/Gleevec)(drug dose-response)
  • KIT DNA analysis - GIST (Imatinib/Gleevec)
  • PDGFRB DNA analysis - Chronic leukemia and myeloproliferative disorders (with eosinophilia)
  • ABL1 DNA analysis (exon 4-10) - Leukemia (Imatinib/Gleevec)
  • DPYD DNA analysis (IVS14+1G>A) - 5-Fluorouracil toxicity
  • JAK2 mutation analysis (V617F) - Myeloproliferative disorders
  • FLT3 mutation analysis (D835) - Acute myeloid leukemia
  • VKORC1 DNA analysis - Warfarin (Coumadin) toxicity
  • VKORC1 S DNA analysis (1173C>T) - Warfarin (Coumadin) toxicity
  • CYP2C9*2 DNA analysis (430C>T) - Warfarin (Coumadin) toxicity
  • CYP2C9*3 DNA analysis (1075A>C) - Warfarin (Coumadin) toxicity
  • CYP3A5*2 DNA analysis (27289C>A) - Xenobitica, toxins and steroid (endogenous substrates)
  • CYP2C19*2 DNA analysis - Cardiovascular disease (Clopidogrel/Plavix resistance)
  • CYP2C19*3 DNA analysis - Cardiovascular disease (Clopidogrel/Plavix resistance)

Molecular Cytogenetics (FISH)

  • Her2/Neu (c-erbB2) FISH analysis - overexpression - Breast cancer (Trastuzumab/Herceptine)
  • EGFR (Her1/erbB1) FISH analysis - overexpression - Lung cancer (Gefitinib/Iressa & Erlotinib/Tarceva)
  • FIP1L1/PDGFRA translocation

Share: